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An experimental procedure to study the diffusion of nanoparticles by MRI
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Plaza-García. Sa, Jiménez-González. Ma, Pastor. Ga, Reese. Ta, Ramos-Cabrer. Pa,b
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a Molecular Imaging Unit, CIC biomaGUNE, Paseo de Miramón 182, 20009 Donostia-San Sebastián, Spain
b Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain
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Abstract |
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The effective distribution of molecules and nanoparticles of biomedical interest through tissues is a key factor for their potential in vivo efficiency. Here we present a simple experimental procedure to measure the diffusion of molecules and nanoparticles than can be traced by Magnetic Resonance Imaging, using agarose as tissue model system. To demonstrate the versatility of the proposed methodology we have: 1) obtained the diffusion coefficients of Gadobutrol (a commercial gadolinium-based contrast agent) at different temperatures, 2) verified the Stoke-Einstein behavior in our experimental setup, 3) determined the size of the particle by MRI and, 4) measured the viscosity of agarose at different compositions. To allow an easy implementation of this experimental set-up, the methodology and data processing procedures are described in detail.
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Keywords
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MRI; Contrast agents; Nanoparticle; Diffusion; Agarose
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