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Sci. Lett. J. 2015, 4: 180
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Research Article
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Full Text
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A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe
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Dik-Lung Maa,b, Modi Wanga, Wanhe Wanga, Lihua Lua, Hui-Min David Wangc, Chung-Hang Leungd
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a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
b Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China
c Department of Fragrance and Cosmetic Science, Graduate Institute of Natural Products, Center for Stem Cell Research,
Kaohsiung Medical University, Taiwan
d State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences,
University of Macau, Macao, China
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Abstract |
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We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.
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Keywords
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Iridium(III) complex; Logic gate; G-quadruplex; i-motif
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