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Journal of Nanoscience Letters 2012, 2: 21
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Research Article
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Solid lipid nanoparticles of ciprofloxacin hydrochloride with enhanced antibacterial activity
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N. Gandomia, E. Aboutaleba, M. Nooria, F. Atyabib, M.R. Fazelic, E.Farbodd, H. Jamalifarc, R. Dinarvanda,b
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a Novel Drug Delivery Systems Lab., Faculty of Pharmacy, Tehran University of Medical Sciences,
Tehran 1417614411, Iran
b Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences,
Tehran 1417614411, Iran
c Department of Drug and Food Control and Pharmaceutical Quality Assurance Research Center,
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran
d Department of Pharmaceutics,
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran
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Abstract |
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Solid lipid nanoparticles (SLN) loaded with ciprofloxacin HCl (CIP) were prepared by a microemulsion technique. Cetyl palmitate was used as the lipid core and polysorbate 80 (T80) as the surfactant. The mean particle size of SLNs, determined by Photon Correlation Spectroscopy (PCS), was 95±3 nm and their zeta potential was -1.9 mv. The entrapment efficacy (EE) and drug loading (DL) were measured using UV/Vis spectrophotometry, reported 54.3% and 7.6% respectively. In vitro release was determined using dialysis bag method in isotonic phosphate buffer pH 7.4. The release profile was biphasic with an initial burst release followed by a plateau and about 60% of the drug was released in the first 24 h. Antibacterial tests were carried out using Broth Micro Dilution technique. The antibacterial activity of CIP-SLN was compared to CIP solution. Drug free SLNs were used as control group. The antibacterial activity of CIP-SLNs against S. aureus and P. aeruginosa was increased significantly compared to CIP solution whilst drug free SLN showed no antibacterial effect.
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Keywords |
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Solid lipid nanoparticles; Ciprofloxacin HCl; Antibacterial activity; Nanotechnology; Drug delivery
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